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Activity, substrate preference and structure of the HsMCM8/9 helicase.
McKinzey DR, Li C, Gao Y, Trakselis MA. McKinzey DR, et al. Nucleic Acids Res. 2023 Aug 11;51(14):7330-7341. doi: 10.1093/nar/gkad508. Nucleic Acids Res. 2023. PMID: 37309874 Free PMC article.
Mutations in these genes are directly linked to ovarian insufficiency, infertility, and several cancers. MCM8/9 appears to have ancillary roles in fork progression and recombination of broken replication forks. However, the biochemical activity, specificities and structure …
Mutations in these genes are directly linked to ovarian insufficiency, infertility, and several cancers. MCM8/9 appears to have ancillary ro …
Ethanol exposure increases mutation rate through error-prone polymerases.
Voordeckers K, Colding C, Grasso L, Pardo B, Hoes L, Kominek J, Gielens K, Dekoster K, Gordon J, Van der Zande E, Bircham P, Swings T, Michiels J, Van Loo P, Nuyts S, Pasero P, Lisby M, Verstrepen KJ. Voordeckers K, et al. Nat Commun. 2020 Jul 21;11(1):3664. doi: 10.1038/s41467-020-17447-3. Nat Commun. 2020. PMID: 32694532 Free PMC article.
In addition, ethanol exposure also results in the recruitment of error-prone DNA polymerases to the replication fork. Interestingly, preventing this recruitment through mutagenesis of the PCNA/Pol30 polymerase clamp or deleting specific error-prone polymerases abolishes th …
In addition, ethanol exposure also results in the recruitment of error-prone DNA polymerases to the replication fork. Interestingly, …